A Weighted Spike-Triggered Average of a Fluctuating Stimulus Yielding the Phase Response Curve

摘要

We demonstrate that the phase response curve (PRC) can be reconstructed usinga weighted spike-triggered average of an injected fluctuating input. The keyidea is to choose the weight to be proportional to the magnitude of thefluctuation of the oscillatory period. Particularly, when a neuron exhibitsrandom switching behavior between two bursting modes, two corresponding PRCscan be simultaneously reconstructed, even from the data of a single trial. Thismethod offers an efficient alternative to the experimental investigation ofoscillatory systems, without the need for detailed modeling.